Use of local hyperoxygenation in diabetic feet: case report.

Diabetes-related diabetic foot ulceration (DFU) is one of the top 10 causes of global disability. The 5-year mortality of patients with DFU has been reported as high as 31%.⁽¹⁾ Topical oxygen may promote DFU healing by several mechanisms: an antimicrobial effect, increasing cellular energy production, promotion of re-epithelialization, stimulation of angiogenesis and enhancement of collagen synthesis. As topical oxygen increases the oxygen tension, leukocytes that depend on oxygen content to generate superoxide species kill bacteria more efficiently. The cells in the ulcer increase production of adenosine triphosphate (ATP) in response to the elevated oxygen levels.⁽²⁾